C- Reactive Protein (CRP) latex slide test (Serology kit) is used for the qualitative and semi-quantitative measurement of C-reactive protein (CRP) in human serum.
C-Reactive Protein (CRP), the classic acute-phase of human serum, is synthesized by hepatocytes. Normally, it is present only in trace amounts in serum, but it can increase by as much as l000-fold in response to injury or infection. The clinical measurement of CRP in serum, therefore, appears to be a valuable screening test for organic disease and a sensitive index of disease activity in inflammatory, infective, and ischemic conditions. 1,2 MacLeod and Avery found that antibody produced against purified CRP provided a more sensitive test than the C-polysaccharide assay. 3 Since that time a number of immunological assays have been devised to measure CRP such as capillary precipitation, double immunodiffusion, and radical immunodiffusion. 4,5
The CRP reagent kit is based on the principle of the latex agglutination assay described by Singer and Plotz. 6 The major advantage of this method is the rapid three (3) minute reaction time.
The CRP reagent kit (Serology Kit) is based on an immunological reaction between CRP antisera bound to biologically inert latex particles and CRP in the test specimen. When serum containing greater than 0.8 mgdl CRP is mixed with the latex reagent, visible agglutination occurs.