3 in 1 Troponin I/Myoglobin/CK-MB Serum Rapid Test description:

Diagnostic Automation/Cortez Diagnostics Inc. offers a 3 in 1 Troponin I/Myoglobin/CK-MB Serum Rapid Test (Cassette) RapiCard Insta Test which is an immunochromatography-based one-step in vitro test for diagnostic. This 3 in 1 Cardiac Markers Rapid Test is designed for qualitative determination of cardiac Troponin I, CK-MB, and Myoglobin in human serum specimen as an aid in the diagnosis of myocardial infarction.




Materials Provided with 3 in 1 Cardiac Markers Rapid Test kit:
1. 3 in 1 Cardiac Markers Rapid Test Cassette

Materials required but not provided:
1. Vacutainer tube, without anticoagulant
2. Timer or clock
3. Micropipetter & tips




3 in 1 Cardiac Markers Rapid Test kit Background Information
Troponin I (cTnI) is a cardiac muscle protein, together with troponin T (TnT) and troponin C (TnC), TnI forms a troponin complex in heart to play a fundamental role in the transmission of intracellular calcium signal actin-myosin interaction. The human cTnI has an additional amino
acid residues on its N-terminal that are not exist on the skeletal forms thus making cTnI a specific marker for indicating cardiac infarction. cTnI is released rapidly into blood after the onset of acute myocardial infarction (AMI). Its release pattern is similar to CK-MB (4-6 hours
after the onset of AMI). However, CK-MB level returns to normal after 36-48 hours, while levels of cTnI remains elevated for up to 6-10 days. The level of cTnI is very low in normal healthy people, and not detected in patients with skeletal muscle injury. Therefore, cTnI is a specific marker for diagnosis of acute myocardial infarction.
Creatine kinase is a dimer occurring in various in three isoenzymic forms, depending on the particular combination of its non-identical subunits:BB(brain type);MM(skeletal type); and MB(hybrid type). Creatine kinase-MB isoenzyme is released into circulation later than myoglubin, reaching abnormal levels within 4 to 6 hours after onset of symptoms, it reaches its highest level with a typical range of 39-185 ng/mL after about 18 to 24 hours,and returns to normal in about 2 to 3 days.CK-MB is widely recognized as the traditional marker for the
diagnosis of AMI.
Myoglobin is a low molecular weight, cytoplasmic serum protein. Due to its low molecular weight, myoglobin is released more rapidly when muscle cells are damaged than other markers. Serum concentration of myoglobin increases above the normal range as early as 1 hour after
myocardial infarction, and peak in approximately 4 to 8 hours after onset. Therefore, myoglobin is better suited for the early diagnosis of AMI.




Myoglobin Rapid Test Principle
The 3 in 1 Cardiac Markers Rapid Test is a sandwich immunoassay where the antigen is sandwiched between two antibodies. If cardiac markers are present at levels of cut-off level or greater, the result is the formation of a colored band in the test region. If there are no cardiac markers in the sample, the area will remain colorless. The sample continues to move to the control area and forms a pink to purple color, indicating the 3 in 1 Cardiac Markers test is working and the result is valid. See Product Insert for more details on test preparation, procedures, and evaluating results.





Diagnostic Automation Inc. offers an additional 3 in 1 Cardiac Marker Rapid Test-the Troponin I/Myoglobin/CK-MB Rapid Test for Serum/Whole Blood specimen. Other Cardiac Markers Rapid Tests such as Myoglobin Rapid Test, the CRP Serum Rapid Test are available, along with Cardiac Markers ELISA Tests. Please see our home page product list, or contact our Customer Service Representatives for more information.




For a complete list of Rapid Tests, ELISA tests, IFA Kits, Serology Tests, and available testing Instrumentation, please visit our website home page or contact our Customer Service Representatives at 818-591-3030.