Malaria pf/pv Rapid Test description:

Los Angeles based Diagnostic Automation/Cortez Diagnostics, Inc. offers a Malaria Rapid diagnostic Test for Malaria pf and pv antigens. This Malaria Rapid Test is a rapid, qualitative test for the detection of Plasmodium falciparum and/or Plasmodium vivax in whole blood. The Malaria Rapid Test is for In-Vitro Diagnostic use.

 

Users of this Malaria Rapid Test know that Malaria is one of the world’s most prevalent parasitic diseases and ranks third in the world's major infectious diseases in terms of mortality. The protozoal parasites that cause malaria are from the Plasmodium genus. When using this Malaria Rapid Test, it is important to know that four species of Plasmodium protozoa cause malaria: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale. Transmitted principally by the Anopheles mosquito, malaria infections may also occur from contacting infected blood, such as from blood transfusions. P. falciparum accounts for the majority of infections and is the most lethal. P. vivax, P. malariae and P. orale cause a less severe form of malaria with intermittent fever which is usually neither debilitating nor fatal.  Those who inquire about the Malaria Rapid Test are familiar with the classic symptoms of malaria:  fever, headaches, chills, vomiting, shivering and convulsions. In some rare forms of falciparum malaria, chills and fever may be absent and the patient may present with delirium or coma; this fact alone shows why it is important to be familiar with how well these Malaria Rapid Tests work. Remission periods can last from a few weeks to several months. Severe anemia is often attributed to the cause of death from a malaria infection.  In all cases, use of the Malaria Rapid Tests is vital to the health and well being of all clients being tested.

 

When administering this Malaria Rapid Test, know that Malaria is a curable disease with a host of drugs that can be used in both its treatment and prevention. Two of the best known and most commonly used are chloroquinine and qui- nine. The early detection of P. falciparum malaria, by use of this Malaria Rapid Test, is of great importance due to rising levels of drug resistance now being associated with this disease.

 

This Malaria Rapid Test will differentiate between the two species:  Plasmodium falciparum and fPlasmodium viavax.

 

The Diagnostic Automation/Cortez Diagnostics, Inc. Malaria Rapid Test is a rapid, in-vitro immunodiagnostic test for the detection of circulating Malaria antigens in whole blood. The Malaria rapid test uses antibodies that are specific for the histidine-rich protein 2 antigen (HRP-2) of Malaria P.f. and Plasmodium aldolase for the detection of all malaria Plasmodium species. Whole blood (5 uL) is applied to the sample port on the Malaria rapid test where the red blood cells are lysed with a specially formulated solution. The label pad that is contained in the Malaria rapid test is impregnated with blue latex that has an anti-HRP-2 antibody coupled to it, along with a second blue latex that has an anti-aldolase antibody coupled to it. The label pad on the Malaria rapid test is also impregnated with purple latex that is coupled to a control antibody. An additional anti- HRP-2 antibody is immobilized on the Malaria rapid test at the P.f. test line region. Another antialdolase antibody is immobilized on the Malaria rapid test strip at the All test line region. Finally, a control material is immobilized at the control line region on the Malaria rapid test.  When a positive sample is applied to the sample port, malaria antigen in the sample contacts the latex-labeled antibody and binds to it. A washing reagent is then added to the buffer well. As the liquid flows along the length of the Malaria rapid test device, any antigen-latex complexes also migrate with the liquid. These complexes are captured by their respective antibodies at the P.f., All and control line regions. If a sample contains P.f. antigen, a blue line will form in the P.f. test region and may or may not form in the All test region, depending on the titer of the antigen present. If the sample contains P.v., P.o. or P.m. antigen, a test line will form in the All test region. If no malaria antigen is present on the Malaria rapid test, a blue line will not form in either P.f. or All test regions. A purple control line will always appear in the control region if the Malaria rapid test has been performed properly.

 

Diagnostic Automation/Cortez Diagnostics offers two formats of the Malaria Rapid Test.  This Malaria Rapid Test for pf and pv antigens and the Malaria Rapid Test for Pan-LDH antibodies.  For more information regarding these Malaria Rapid Tests, please contact Customer Service.